{"id":591,"date":"2008-10-26T20:37:15","date_gmt":"2008-10-26T11:37:15","guid":{"rendered":"http:\/\/testwww.seibutsushi.net\/blog\/2008\/10\/560.html"},"modified":"2008-10-26T20:37:15","modified_gmt":"2008-10-26T11:37:15","slug":"%e3%82%bb%e3%83%ab%e3%83%88%e3%83%aa%e7%b4%b0%e8%83%9e%e3%81%aey%e6%9f%93%e8%89%b2%e4%bd%93%e3%81%8c%e7%b2%be%e5%ad%90%e3%81%ae%e9%81%ba%e4%bc%9d%e5%ad%90%e3%82%92%e5%88%b6%e5%be%a1%e3%81%97%e3%81%a6","status":"publish","type":"post","link":"http:\/\/www.seibutsushi.net\/blog\/2008\/10\/591.html","title":{"rendered":"\u30bb\u30eb\u30c8\u30ea\u7d30\u80de\u306eY\u67d3\u8272\u4f53\u304c\u7cbe\u5b50\u306e\u907a\u4f1d\u5b50\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b"},"content":{"rendered":"<p>\u751f\u7269\u53f2\u30d6\u30ed\u30b0\u306e<a href=\"http:\/\/www.biological-j.net\/blog\/2008\/10\/000579.html\">\u300c\u7cbe\u5b50\u306e\u4e73\u6bcd\uff01\uff1f\u300e\u30bb\u30eb\u30c8\u30ea\u7d30\u80de\u300f\u306e\u5f79\u5272\u3063\u3066\uff1f\uff1f\u300d<\/a>\u306b\u5bc4\u305b\u3089\u308c\u3066\u3044\u305f\u3001\u4ee5\u4e0b\u306e\u30b3\u30e1\u30f3\u30c8\u306b\u3064\u3044\u3066\u8abf\u3079\u3066\u307f\u307e\u3057\u305f\u3002<\/p>\n<blockquote><p>\uff1e\u3053\u3093\u306a\u8a18\u4e8b\u307f\u3064\u3051\u307e\u3057\u305f\u3002<br \/>\n\u2193<br \/>\n<a href=\"http:\/\/www.nibb.ac.jp\/seibunka\/publi\/publi_kanai.html\">\u6027\u5206\u5316\u6a5f\u69cb\u306e\u89e3\u660e<\/a><br \/>\n\u54fa\u4e73\u985e\u306e\u7cbe\u5b50\u767a\u751f\u306b\u304a\u3051\u308b\u4f53\u7d30\u80de\u5074\u3067\u306eY\u67d3\u8272\u4f53\u306e\u5f79\u5272\u306b\u3064\u3044\u3066\u3001\u4ee5\u4e0b\u306e\uff12\u70b9\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002<br \/>\n\uff11\uff09\u7cbe\u5de3\u6c7a\u5b9a\u907a\u4f1d\u5b50Sry\u306b\u3088\u308b\u7cbe\u5de3\u3078\u306e\u5206\u5316\u6c7a\u5b9a\u4ee5\u5f8c\u3001\u601d\u6625\u671f\u3067\u306e\u534a\u6570\u4f53\u5f62\u6210(\u5186\u5f62\u7cbe\u5b50\u7d30\u80de)\u307e\u3067\u306f\u3001\u4f53\u7d30\u80de\u5074 (\u7cbe\u5de3\u3001\u4e0b\u5782\u4f53\u3001\u8996\u5e8a\u4e0b\u90e8\u3092\u542b\u3081\u4f53\u4e2d\u306e\u5168\u3066\u306e\u4f53\u7d30\u80de)\u3067Y\u67d3\u8272\u4f53\u306f\u4e0d\u8981\u3067\u3042\u308b\u3002<br \/>\n\uff12\uff09\u5186\u5f62\u7cbe\u5b50\u7d30\u80de\u304b\u3089\u7cbe\u5b50\u307e\u3067\u306e\u7cbe\u5b50\u5f62\u6210\u306b\u3001Y\u67d3\u8272\u4f53\u4e0a\u306eDdx3y, Uty, Ubely1, Eif2s3y, Jarid1d\uff08\u5168\u3066\u3042\u308b\u3044\u306f\u3053\u306e\u4e00\u90e8\uff09\u304c\u30bb\u30eb\u30c8\u30ea\u7d30\u80de\u3067\u91cd\u8981\u3067\u3042\u308a\u3001\u5e7e\u3064\u304b\u306e\u7cbe\u5b50\u5f62\u6210\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u30bb\u30eb\u30c8\u30ea\u7d30\u80de\u3067\u306e\u767a\u73fe\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u7cbe\u5b50\u3078\u306e\u5f62\u614b\u5f62\u6210\u3092\u652f\u6301\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u63a8\u6e2c\u3055\u308c\u305f\u3002<br \/>\n\u30fb\u30fb\u30fb<br \/>\n\u4e0a\u8a18\u3060\u3051\u3067\u306f\u5224\u7136\u3068\u3057\u307e\u305b\u3093\u304c\u3001<br \/>\n\u30bb\u30eb\u30c8\u30ea\u7d30\u80de\u306b\u304a\u3051\u308bY\u67d3\u8272\u4f53\u3063\u3066\u3001\u4f55\u304b\u91cd\u8981\u306a\u50cd\u304d\u3092\u3057\u3066\u3044\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u306d\u3002<\/p><\/blockquote>\n<p>\u5fa9\u7fd2\u306b\u306a\u308a\u307e\u3059\u304c\u3001\u30bb\u30eb\u30c8\u30ea\u7d30\u80de\u306f\u3001\u7cbe\u5b50\u306e\u5143\u306b\u306a\u308b\u7cbe\u539f\u7d30\u80de\u304c\u7cbe\u5b50\u306b\u6210\u9577\u3057\u3066\u3044\u304f\u306e\u3092\u52a9\u3051\u3066\u3044\u308b\u7d30\u80de\u3067\u3059\u3002<br \/>\n<img loading=\"lazy\" alt=\"%E3%82%BB%E3%83%AB%E3%83%88%E3%83%AA%E7%B4%B0%E8%83%9E%E3%81%A8%E7%B2%BE%E5%B7%A3.bmp\" src=\"\/blog\/wp-content\/uploads\/%E3%82%BB%E3%83%AB%E3%83%88%E3%83%AA%E7%B4%B0%E8%83%9E%E3%81%A8%E7%B2%BE%E5%B7%A3.bmp\" width=\"440\" height=\"139\" \/><br \/>\n\u3053\u306e\u753b\u50cf\u306f<a href=\"http:\/\/www.kyoto-u.ac.jp\/notice\/05_news\/documents\/070907_1.htm\">\u4eac\u90fd\u5927\u5b66\u306e\u30cb\u30e5\u30fc\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>\u304b\u3089\u304a\u501f\u308a\u3057\u307e\u3057\u305f<br \/>\n\u30bb\u30eb\u30c8\u30ea\u7d30\u80de\u306eY\u67d3\u8272\u4f53\u304c\u3069\u3093\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u306e\u304b\u3001\u8208\u5473\u306e\u3042\u308b\u65b9\u306f\u5fdc\u63f4\u304a\u9858\u3044\u3057\u307e\u3059\u3002<br \/>\n<a href=\"http:\/\/blog.with2.net\/link.php?548466\" target=\"_blank\"><img alt=\"\u30d6\u30ed\u30b0\u30e9\u30f3\u30ad\u30f3\u30b0\u30fb\u4eba\u6c17\u30d6\u30ed\u30b0\u30e9\u30f3\u30ad\u30f3\u30b0\u3078\" src=\"\/blog\/wp-content\/uploads\/banner_04.gif\" \/><\/a><a href=\"http:\/\/science.blogmura.com\/\" target=\"_blank\"><img loading=\"lazy\" height=\"15\" alt=\"\u306b\u307b\u3093\u30d6\u30ed\u30b0\u6751 \u79d1\u5b66\u30d6\u30ed\u30b0\u3078\" src=\"http:\/\/science.blogmura.com\/img\/science80_15.gif\" width=\"80\" \/><\/a><a href=\"http:\/\/blogranking.fc2.com\/in.php?id=92199\" target=\"_blank\"><img src=\"\/blog\/wp-content\/uploads\/pic\/e_03.gif\" \/><\/a><\/p>\n<p><!--more--><br \/>\nY\u67d3\u8272\u4f53\u304c\u6700\u521d\u306b\u50cd\u304f\u306e\u306f\u767a\u751f\u521d\u671f\u3067\u3059\u3002\u5375\u5de3\u306b\u3082\u7cbe\u5de3\u306b\u3082\u306a\u308a\u3048\u308b\u751f\u6b96\u817a\u304c\u7cbe\u5de3\u306b\u306a\u308b\u306e\u306f\u3001Y\u67d3\u8272\u4f53\u4e0a\u306eSry\u907a\u4f1d\u5b50\u304c\u767a\u73fe\u3057\u69d8\u3005\u306a\u7cbe\u5de3\u5f62\u6210\u907a\u4f1d\u5b50\u304c\u50cd\u304d\u51fa\u3059\u304b\u3089\u3067\u3059\u3002<br \/>\n\u305d\u3057\u3066\u3001\u6b21\u306bY\u67d3\u8272\u4f53\u304c\u50cd\u304f\u306e\u306f\u3001\u7b2c\u4e8c\u6b21\u6027\u5fb4\u3092\u7d4c\u3066\u3001\u672c\u683c\u7684\u306b\u7cbe\u5b50\u3092\u751f\u7523\u3059\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u304b\u3089\u306e\u3088\u3046\u3067\u3059\u3002<br \/>\n\u7cbe\u5de3\u5185\u3067\u7cbe\u5b50\u304c\u751f\u7523\u3055\u308c\u308b\u6d41\u308c\u306f\u3001\u7cbe\u7d44\u7d30\u80de\u2192\u524d(\u7b2c\u4e00\u6b21)\u7cbe\u6bcd\u7d30\u80de\u2192(\u7b2c\u4e8c\u6b21)\u7cbe\u6bcd\u7d30\u80de\u2192(\u524d\u671f\uff65\u5f8c\u671f)\u7cbe\u5b50\u7d30\u80de\u2192\u7cbe\u5b50\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<br \/>\n\u3053\u308c\u3089\u306e\u7cbe\u5b50\u751f\u7523\u306e\u904e\u7a0b\u306f\u3001\u30bb\u30eb\u30c8\u30ea\u7d30\u80de\u304c\u5206\u6ccc\u3059\u308b\u7269\u8cea(\u30ea\u30ac\u30f3\u30c9SCF)\u304c\u7cbe\u7956\u7d30\u80de\u306e\u53d7\u5bb9\u4f53(\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bcc-Kit)\u306b\u53d7\u3051\u5165\u308c\u3089\u308c\u308b\u3053\u3068\u3067\u9032\u3093\u3067\u3044\u308b\u305d\u3046\u3067\u3059\u3002<br \/>\n<img loading=\"lazy\" alt=\"%E3%83%81%E3%83%AD%E3%82%B7%E3%83%B3%E3%82%AD%E3%83%8A%E3%83%BC%E3%82%BC.jpg\" src=\"\/blog\/wp-content\/uploads\/%E3%83%81%E3%83%AD%E3%82%B7%E3%83%B3%E3%82%AD%E3%83%8A%E3%83%BC%E3%82%BC.jpg\" width=\"488\" height=\"434\" \/><br \/>\n\u3053\u306e\u753b\u50cf\u306f<a href=\"http:\/\/www.gist.jp\/pdf\/3_alldata.pdf#search='\u30ea\u30ac\u30f3\u30c9SCF'\">GIST\u306e\u767a\u751f\u6a5f\u69cb<\/a>\u304b\u3089\u304a\u501f\u308a\u3057\u307e\u3057\u305f<br \/>\n\u203b\uff11\u3001\u30ea\u30ac\u30f3\u30c9<br \/>\n\u4e3b\u306b\u7d30\u80de\u819c\u8868\u9762\u4e0a\u306b\u5b58\u5728\u3059\u308b\u53d7\u5bb9\u4f53\u306b\u7d50\u5408\u3057\u7d30\u80de\u5185\u306b\u30b7\u30b0\u30ca\u30eb\u3092\u4f1d\u3048\u308b\u7d30\u80de\u5916\u306e\u7269\u8cea\u3067\uff0c\u5404\u7a2e\u30db\u30eb\u30e2\u30f3\uff0c\u5897\u6b96\u56e0\u5b50\u3092\u542b\u3080\u3002KIT\u306b\u5bfe\u3059\u308b\u30ea\u30ac\u30f3\u30c9\u306fSCF\u3067\u3042\u308b\u3002\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\uff08tyrosine kinase\uff09<br \/>\n\u203b\uff12\u3001SCF<br \/>\n\u9aa8\u9ac4\u9593\u8cea\u7d30\u80de\u306a\u3069\u3067\u7523\u751f\u3055\u308c\uff0c\u9020\u8840\u306a\u3069\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3002\u53d7\u5bb9\u4f53\u578b\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u3067\u3042\u308bKIT\u306e\u30ea\u30ac\u30f3\u30c9\u3002SCF\u304cKIT\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u306b\u3088\u308a\uff0c\u7d30\u80de\u5897\u6b96\u306a\u3069\u306e\u30b7\u30b0\u30ca\u30eb\u304c\u7d30\u80de\u5185\u306b\u4f1d\u9054\u3055\u308c\u308b\u3002\u305f\u3068\u3048\u3070\uff0c\u6025\u6027\u9aa8\u9ac4\u6027\u767d\u8840\u75c5\u306e\u82bd\u7403\u306f\u9ad8\u983b\u5ea6\u306bKIT\u3092\u767a\u73fe\u3057\u3066\u3044\u308b\u305f\u3081\uff0cSCF\u5b58\u5728\u4e0b\u3067\u305d\u306e\u5897\u6b96\u304c\u4fc3\u9032\u3055\u308c\u308b\u3002<br \/>\n\u203b\uff13\u3001\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\uff08tyrosine kinase\uff09<br \/>\n\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\uff08\u86cb\u767d\u8cea\u30ea\u30f3\u9178\u5316\u9175\u7d20\uff09\u306e\uff11\u3064\u3067\uff0c\u30c1\u30ed\u30b7\u30f3\u6b8b\u57fa\u3092\u7279\u7570\u7684\u306b\u30ea\u30f3\u9178\u5316\u3059\u308b\u9175\u7d20\u306e\u7dcf\u79f0\u3002\u7d30\u80de\u819c\u3092\u8cab\u901a\u3059\u308b\u30c9\u30e1\u30a4\u30f3\u3092\u6709\u3059\u308b\u53d7\u5bb9\u4f53\u578b\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u3068\u7d30\u80de\u819c\u3092\u8cab\u901a\u3057\u306a\u3044\u975e\u53d7\u5bb9\u4f53\u578b\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u306b\u5206\u3051\u3089\u308c\uff0c\u30ea\u30ac\u30f3\u30c9\u3068\u7d50\u5408\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u7d30\u80de\u5185\u306b\u7d30\u80de\u5897\u6b96\u30fb\u5206\u5316\u306a\u3069\u306e\u30b7\u30b0\u30ca\u30eb\u3092\u4f1d\u9054\u3059\u308b\u3002<br \/>\n\u7cbe\u5b50\u306f\u81ea\u767a\u7684\u306b\u7cbe\u7956\u7d30\u80de\u304b\u3089\u6e1b\u6570\u5206\u88c2\u3084\u5f62\u614b\u5909\u5316\u3092\u8d77\u3053\u3057\u7cbe\u5b50\u306b\u306a\u3063\u3066\u3044\u304f\u308f\u3051\u3067\u306f\u306a\u304f\u3001\u30bb\u30eb\u30c8\u30ea\u7d30\u80de\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u7269\u8cea\u306e\u6307\u4ee4\u3092\u53d7\u3051\u3066\u3001\u521d\u3081\u3066\u7cbe\u5b50\u3078\u3068\u5909\u5316\u3057\u3066\u3044\u308b\u306e\u3067\u3059\u3002<br \/>\n<img loading=\"lazy\" alt=\"%E7%B2%BE%E5%AD%90%E5%BD%A2%E6%88%90.jpg\" src=\"\/blog\/wp-content\/uploads\/%E7%B2%BE%E5%AD%90%E5%BD%A2%E6%88%90.jpg\" width=\"500\" height=\"332\" \/><br \/>\n\u3053\u306e\u753b\u50cf\u306f<a href=\"http:\/\/www.miyazaki-med.ac.jp\/anatomy1\/kenkyu\/kenkyu2_2.html#Anchor-39952\">\u7cbe\u5b50\u5f62\u6210\uff08\u767a\u751f\uff09\u306b\u95a2\u3059\u308b\u7814\u7a76<\/a>\u304b\u3089\u304a\u501f\u308a\u3057\u307e\u3057\u305f<br 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