{"id":582,"date":"2008-10-09T16:26:26","date_gmt":"2008-10-09T07:26:26","guid":{"rendered":"http:\/\/testwww.seibutsushi.net\/blog\/2008\/10\/551.html"},"modified":"2008-10-09T16:26:26","modified_gmt":"2008-10-09T07:26:26","slug":"%e5%b0%8f%e3%81%95%e3%81%aa%ef%bd%92%ef%bd%8e%ef%bd%81%ef%bd%9e%e5%a4%89%e7%95%b0%e3%81%a8%e5%ae%89%e5%ae%9a%e3%81%ae%e4%b8%8d%e6%80%9d%e8%ad%b0%e3%81%aa%e4%bb%95%e7%b5%84%e3%81%bf","status":"publish","type":"post","link":"http:\/\/www.seibutsushi.net\/blog\/2008\/10\/582.html","title":{"rendered":"\u5c0f\u3055\u306a\uff32\uff2e\uff21\uff5e\u5909\u7570\u3068\u5b89\u5b9a\u306e\u4e0d\u601d\u8b70\u306a\u4ed5\u7d44\u307f"},"content":{"rendered":"<p>\u4eca\u65e5\u306f\u3001<span style=\"color:#6666ff;\"><strong>\u751f\u6b96\u7d30\u80de\u3068\u5c0f\u3055\u306a\uff32\uff2e\uff21\u306e\u95a2\u4fc2<\/strong><\/span>\u306b\u3064\u3044\u3066\u8003\u3048\u3066\u307f\u307e\u3059\u3002<br \/>\n\u305d\u3057\u3066\u30fb\u30fb\u30fb<br \/>\n\u751f\u7269\u306b\u304a\u3044\u3066\u3001\u5916\u5727\u306b\u3088\u308b\u5909\u7570\u3068\u305d\u306e\u8ee2\u5199\u306f\u3069\u3046\u306a\u3063\u3066\u3044\u308b\u306e\u304b\uff1f\u3000<br \/>\n\u307e\u305f\u3001\u305d\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u304a\u3051\u308b\u30aa\u30b9\u3068\u30e1\u30b9\u306e\u5f79\u5272\u306f\uff1f\u3000<br \/>\n\u3053\u3046\u3057\u305f\u30c6\u30fc\u30de\u306b\u8feb\u3063\u3066\u3044\u304d\u305f\u3044\u3068\u601d\u3044\u307e\u3059 <img src=\"\/blog\/wp-includes\/images\/smilies\/m208.gif\" \/><br \/>\n<br \/>\n\u3053\u3061\u3089\u306e\u30a8\u30f3\u30c8\u30ea\u30fc\u3082\u3054\u3089\u3093\u304f\u3060\u3055\u3044\u306d\u3002<br \/>\n<img src=\"\/blog\/wp-includes\/images\/smilies\/m117.gif\" \/> <a href=\"http:\/\/www.biological-j.net\/blog\/2008\/08\/000550.html\">\u5c0f\u3055\u306a\uff32\uff2e\uff21\u306e\u591a\u69d8\u306a\u306f\u305f\u3089\u304d\u3000<\/a><br \/>\n<img src=\"\/blog\/wp-includes\/images\/smilies\/m117.gif\" \/> <a href=\"http:\/\/www.biological-j.net\/blog\/2008\/09\/000568.html\">\u5c0f\u3055\u306a\uff32\uff2e\uff21\uff08\u7d9a\u7de8\uff09<\/a><br \/>\n<br \/>\n\u6c17\u306b\u306a\u308b\u7d9a\u304d\u306f\u30dd\u30c1\u3063\u3068\u62bc\u3057\u3066\u304b\u3089\u3069\u3046\u305e <img src=\"\/blog\/wp-includes\/images\/smilies\/m030.gif\" \/><br \/>\n<a href=\"http:\/\/blog.with2.net\/link.php?548466\" target=\"_blank\"><img alt=\"\u30d6\u30ed\u30b0\u30e9\u30f3\u30ad\u30f3\u30b0\u30fb\u4eba\u6c17\u30d6\u30ed\u30b0\u30e9\u30f3\u30ad\u30f3\u30b0\u3078\" src=\"\/blog\/wp-content\/uploads\/banner_04.gif\" \/><\/a><br \/>\n<a href=\"http:\/\/science.blogmura.com\/in\/073660.html\" target=\"_blank\"><img loading=\"lazy\" height=\"15\" alt=\"\u306b\u307b\u3093\u30d6\u30ed\u30b0\u6751 \u79d1\u5b66\u30d6\u30ed\u30b0\u3078\" src=\"http:\/\/science.blogmura.com\/img\/science80_15.gif\" width=\"80\" \/><\/a><br \/>\n<a href=\"http:\/\/blogranking.fc2.com\/in.php?id=92199\" target=\"_blank\"><img src=\"\/blog\/wp-content\/uploads\/pic\/e_03.gif\" \/><\/a><\/p>\n<p><!--more--><br \/>\n<br \/>\n<strong><span style=\"color:#ff3300;\">\u25cf\u5375\u306b\u767a\u73fe\u3059\u308b\u3001\u30ec\u30c8\u30ed\u30c8\u30e9\u30f3\u30b9\u30dd\u30be\u30f3\u306b\u3088\u308b\u5909\u7570\u3092\u6291\u5236\u3059\u308bsmall\uff32\uff2e\uff21\uff08siRNA\uff09<\/span><\/strong><br \/>\n<a href=\"http:\/\/www.nig.ac.jp\/hot\/press\/0410sasakimore.html\">\u54fa\u4e73\u985e\u521d\u3001\u30de\u30a6\u30b9\u5375\u5b50\u304b\u3089\u5185\u5728\u6027siRNA\u3092\u767a\u898b<\/a>\u3000\u3088\u308a<\/p>\n<blockquote><p>\u672c\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u5185\u5728siRNA\u304c\u4f5c\u308a\u51fa\u3055\u308c\u308b\u306e\u306b\u5fc5\u8981\u306a\u30c0\u30a4\u30b5\u30fc\u5207\u65ad\u9175\u7d20\u3092\u6b20\u640d\u3055\u305b\u305f\u5375\u5b50\u3067\u3001\u30ec\u30c8\u30ed\u30c8\u30e9\u30f3\u30b9\u30dd\u30be\u30f3\u306e\u50cd\u304d\u304c\u6d3b\u767a\u5316\u3057\u3066\u3044\u305f\u3053\u3068\u304b\u3089\u3001\u5185\u5728siRNA\u304c\u30ec\u30c8\u30ed\u30c8\u30e9\u30f3\u30b9\u30dd\u30be\u30f3\u306e\u767a\u73fe\u3092\u6291\u5236\u3057\u3066\u3044\u308b\u3068\u7d50\u8ad6\u3065\u3051\u307e\u3057\u305f\u3002<br \/>\n\u30ec\u30c8\u30ed\u30c8\u30e9\u30f3\u30b9\u30dd\u30be\u30f3\u3068\u306f\u3001\u30b2\u30ce\u30e0\u306b\u5bc4\u751f\u3057\u3066\u81ea\u5206\u306e\u30b3\u30d4\u30fc\u3092\u5897\u3084\u3059\u907a\u4f1d\u56e0\u5b50\u306e\u4e00\u7a2e\u3067\u3059\u3002<br \/>\n\u5897\u3048\u305f\u30b3\u30d4\u30fc\u304c\u5225\u306e\u907a\u4f1d\u5b50\u306e\u5834\u6240\u306b\u633f\u5165\u3055\u308c\u308b\u3068\u7a81\u7136\u5909\u7570\u3092\u8d77\u3053\u3057\u307e\u3059\u3002<br \/>\n\u5185\u5728siRNA\u306b\u3088\u308b\u30ec\u30c8\u30ed\u30c8\u30e9\u30f3\u30b9\u30dd\u30be\u30f3\u306e\u767a\u73fe\u306e\u6291\u5236\u306f\u3001\u907a\u4f1d\u5b50\u306e\u7a81\u7136\u5909\u7570\u3092\u6291\u3048\u3001\u6b63\u5e38\u306a\u30b2\u30ce\u30e0\u3084\u907a\u4f1d\u5b50\u3092\u6b21\u4e16\u4ee3\u306b\u4f1d\u3048\u308b\u306e\u306b\u5f79\u7acb\u3063\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<br \/>\n\u54fa\u4e73\u985e\u306e\u30ec\u30c8\u30ed\u30c8\u30e9\u30f3\u30b9\u30dd\u30be\u30f3\u306b\u306f\u3001\u30b2\u30ce\u30e0\u4e2d\u306b\u6570\u4e07\u30b3\u30d4\u30fc\u3082\u5b58\u5728\u3059\u308b\u3082\u306e\u304c\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u30ec\u30c8\u30ed\u30c8\u30e9\u30f3\u30b9\u30dd\u30be\u30f3\u304c\u52d5\u304d\u56de\u3089\u306a\u3044\u3088\u3046\u6291\u5236\u3059\u308b\u3053\u3068\u306f\u54fa\u4e73\u985e\u306e\u9032\u5316\u306e\u904e\u7a0b\u306b\u304a\u3044\u3066\u3068\u3066\u3082\u91cd\u8981\u3067\u3059\u3002<\/p><\/blockquote>\n<p>\u203bsiRNA\u3068\u306f\u30fb\u30fb\u30fb<br \/>\n\u30fbsmall interfering RNA\u306e\u7565\uff08\u4f4e\u5206\u5b50\u5e72\u6e09RNA\uff09\u3002<br \/>\n\u30fb\u4e8c\u672c\u9396RNA\u304b\u3089Dicer\uff08\u30c0\u30a4\u30b5\u30fc\uff09\u3068\u3088\u3070\u308c\u308b\u5207\u65ad\u9175\u7d20\u306b\u3088\u3063\u3066\u3064\u304f\u3089\u308c\u3001RNA\u5e72\u6e09\uff08\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u8abf\u7bc0\uff09\u3092\u8d77\u3053\u3059\u3002<br \/>\n\u30fb\u54fa\u4e73\u985e\u3060\u3051\u3067\u306a\u304f\u3001\u9175\u6bcd\u3001\u690d\u7269\u3001\u7dda\u866b\u306e\u4f53\u5185\u306b\u5b58\u5728\u3057\u3001\u751f\u7269\u7a2e\u3092\u8d85\u3048\u3066\u4fdd\u5b58\u3055\u308c\u305f\u9032\u5316\u7684\u306b\u91cd\u8981\u306aRNA\u3068\u8003\u3048\u3089\u308c\u308b\u3002<br \/>\n<br \/>\n\u203b\u5c11\u3057\u3084\u3084\u3053\u3057\u3044\u3068\u3053\u308d\u3067\u3059\u304c\u3001siRNA\u306f\u3069\u3046\u3084\u3063\u3066\u3064\u304f\u3089\u308c\u308b\u304b\u3068\u3044\u3046\u3068\u3001\u507d\u907a\u4f1d\u5b50\uff08\uff24\uff2e\uff21\u914d\u5217\u306e\u3046\u3061\u5909\u7570\u3092\u84c4\u7a4d\u3057\u305f\u90e8\u5206\uff09\u3082\u3057\u304f\u306f\u30ec\u30c8\u30ed\u30c8\u30e9\u30f3\u30b9\u30dd\u30be\u30f3\u3092\u3082\u3068\u306b\u3064\u304f\u3089\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n<br \/>\n<strong><span style=\"color:#ff3300;\">\u25cf\u7cbe\u5de3\u3067\u767a\u73fe\u3059\u308bsmall\uff32\uff2e\uff21\u3001\u305d\u306e\u5f79\u5272\u306f\uff1f<\/span><\/strong><br \/>\n\u7cbe\u5de3\u3067\u306f\u3001\u5375\u306b\u767a\u73fe\u3059\u308bsiRNA\u3084\u3001miRNA\uff08\u30de\u30a4\u30af\u30ed\uff32\uff2e\uff21\uff09\u3068\u306f\u7570\u306a\u308b\u3001\u5225\u306e\u30bf\u30a4\u30d7\u306esmall RNA\u304c\u50cd\u3044\u3066\u3044\u307e\u3059\u3002<br \/>\n<br \/>\n<a href=\"http:\/\/www.nig.ac.jp\/hot\/2008\/sasaki0804-j.html\">\u30de\u30a6\u30b9\u7cbe\u5de3\u306b\u304a\u3051\u308b\u30ec\u30c8\u30ed\u30c8\u30e9\u30f3\u30b9\u30dd\u30be\u30f3\u306eDNA\u30e1\u30c1\u30eb\u5316\u306fPiwi\u30d5\u30a1\u30df\u30ea\u30fc\u86cb\u767d\u8cea\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u308b<\/a>\u3000\u3088\u308a<\/p>\n<blockquote><p>\u54fa\u4e73\u985e\u306e\u7cbe\u5b50\u3092\u4f5c\u308b\u96c4\u6027\u751f\u6b96\u7d30\u80de\u306b\u304a\u3044\u3066\u3001small RNA\u306e\u5236\u5fa1\u7cfb\u3068de novo DNA\u30e1\u30c1\u30eb\u5316\u306e\u5236\u5fa1\u7cfb\u306e\u9593\u306b\u30af\u30ed\u30b9\u30c8\u30fc\u30af\u304c\u3042\u308b\u3053\u3068\u304c\u767a\u898b\u3055\u308c\u307e\u3057\u305f\u3002<br \/>\nPiwi\u30bf\u30f3\u30d1\u30af\u8cea\u306fpiRNA\u3068\u3088\u3070\u308c\u308b25-32 nt\u306esmall RNA\u3068\u7d50\u5408\u3057\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u5236\u5fa1\u306b\u50cd\u3044\u3066\u3044\u307e\u3059\u3002<br \/>\n\u4eca\u56de\u3001Piwi\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u306b\u304a\u3051\u308bDNA\u30e1\u30c1\u30eb\u5316\u89e3\u6790\u3001\u304a\u3088\u3073\u80ce\u751f\u671f\u7cbe\u5de3\u306b\u304a\u3051\u308b\u7db2\u7f85\u7684small RNA\u306e\u89e3\u6790\u306b\u3088\u3063\u3066\u3001Piwi\u3068piRNA\u304c\u80ce\u751f\u671f\u306e\u30de\u30a6\u30b9\u7cbe\u5de3\u306b\u304a\u3044\u3066\u30ec\u30c8\u30ed\u30c8\u30e9\u30f3\u30b9\u30dd\u30be\u30f3\u306ede novo DNA\u30e1\u30c1\u30eb\u5316\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/p><\/blockquote>\n<p>\u3064\u307e\u308a\u3001\u7cbe\u5de3\u3067\u767a\u73fe\u3059\u308bsmall\uff32\uff2e\uff21\u306f\uff24\uff2e\uff21\u306e\u30e1\u30c1\u30eb\u5316\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3089\u3057\u3044\u3002<br \/>\n<br \/>\n\u307e\u305f\u3001\u7cbe\u5de3\u3067\u767a\u73fe\u3059\u308bsmall\uff32\uff2e\uff21\uff08pi\uff32\uff2e\uff21\u3001gs\uff32\uff2e\uff21\u306a\u3069\u3068\u547c\u3070\u308c\u3066\u3044\u308b\uff09\u306f\u3001\u6e1b\u6570\u5206\u88c2\u524d\u671f\u306e\u7cbe\u6bcd\u7d30\u80de\u304b\u3089\u6e1b\u6570\u5206\u88c2\u5f8c\u306e\u5186\u5f62\u7cbe\u5b50\u7d30\u80de\u306b\u304b\u3051\u3066\u767a\u73fe\u3057\u3066\u3044\u308b\u3089\u3057\u304f\u3001\u7cbe\u5b50\u5f62\u6210\u306b\u3082\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3089\u3057\u3044\u3002<br \/>\n<br \/>\n\u3053\u308c\u306f\u4f55\u3092\u610f\u5473\u3059\u308b\u306e\u304b\uff1f\uff1f\uff1f<br \/>\n<br \/>\n\u203b\uff24\uff2e\uff21\u30e1\u30c1\u30eb\u5316\u3068\u306f\u30fb\u30fb\u30fb<br \/>\n\u30fb\uff24\uff2e\uff21\u306e\u30e1\u30c1\u30eb\u5316\uff08\uff23\uff28\uff13\u304c\u4ed8\u304f\uff09\u4fee\u98fe\u306f\u3001\uff23\uff08\u30b7\u30c8\u30b7\u30f3\uff09\u3068\uff27\uff08\u30b0\u30a2\u30cb\u30f3\uff09\u304c\u9023\u7d9a\u3059\u308b\u90e8\u4f4d\u306b\u591a\u304f\u898b\u3089\u308c\u308b\u3002<br \/>\n\u30fb\u521d\u671f\u80da\u767a\u751f\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u8abf\u6574\u3001\u67d3\u8272\u4f53\u306e\u5b89\u5b9a\u5316\u3001\uff24\uff2e\uff21\u8907\u88fd\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u3001\u7d30\u80de\u306e\u764c\u5316\u306a\u3069\u3001\u69d8\u3005\u306a\u73fe\u8c61\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3068\u8a00\u308f\u308c\u308b\u3002<br \/>\n\u30fb\u30e1\u30c1\u30eb\u5316\u90e8\u5206\u306f\u907a\u4f1d\u5b50\u767a\u73fe\u5909\u7570\u304c\u3088\u304f\u8d77\u3053\u308b\u90e8\u4f4d\u3068\u306a\u308b\u3002<br \/>\n\u30fb\u9032\u5316\u53f2\u7684\u306b\u306f\u3001\u9175\u6bcd\u3001\u7dda\u866b\u3001\u30cf\u30a8\u306a\u3069\u306e\u30b2\u30ce\u30e0\u306f\u30e1\u30c1\u30eb\u5316\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u810a\u690e\u52d5\u7269\u4ee5\u964d\u306b\u8457\u3057\u304f\u30e1\u30c1\u30eb\u5316\u306e\u7a0b\u5ea6\u304c\u4e0a\u6607\u3057\u3066\u3044\u308b\u3002<br \/>\n<br \/>\n\u203b\u53c2\u8003\uff1a<a href=\"http:\/\/bunseiri.hp.infoseek.co.jp\/DNApage.htm\">\u30d3\u30b8\u30e5\u30a2\u30eb\u751f\u7406\u5b66<\/a>\u3000<br \/>\n<br \/>\n\u307e\u305f\u3001\u690d\u7269\u306b\u304a\u3044\u3066\u3082\u3001\u8208\u5473\u6df1\u3044\u73fe\u8c61\u304c\u767a\u898b\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u5916\u5727\u5909\u5316\uff08\u74b0\u5883\u30b9\u30c8\u30ec\u30b9\u3001\u6e29\u5ea6\u5909\u5316etc\uff09\u306b\u6652\u3055\u308c\u305f\u690d\u7269\u306f\u3001DNA\u306e\u30e1\u30c1\u30eb\u5316\uff0f\u8131\u30e1\u30c1\u30eb\u5316\u3092\u4f7f\u3063\u3066\u6570\u767e\u500b\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u5909\u52d5\u3055\u305b\u3001\u5371\u6a5f\u3092\u56de\u907f\u3059\u308b\u6a5f\u69cb\u3092\u3082\u3063\u3066\u3044\u307e\u3059\u3002\u3064\u307e\u308a\u74b0\u5883\u5909\u5316\u306b\u5bfe\u5fdc\u3059\u308b\u907a\u4f1d\u5b50\u306e\u30b9\u30a4\u30c3\u30c1\u30aa\u30f3\uff0f\u30aa\u30d5\u306e\u30ad\u30fc\u3068\u306a\u3063\u3066\u3044\u308b\u306e\u304cDNA\u30e1\u30c1\u30eb\u5316\u306b\u306a\u3063\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002<br \/>\n<br \/>\n<strong><span 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