{"id":570,"date":"2008-09-22T23:41:15","date_gmt":"2008-09-22T14:41:15","guid":{"rendered":"http:\/\/testwww.seibutsushi.net\/blog\/2008\/09\/540.html"},"modified":"2008-09-22T23:41:15","modified_gmt":"2008-09-22T14:41:15","slug":"%e7%b4%b0%e8%83%9e%e5%91%a8%e6%9c%9f%e3%81%a8%e4%b8%ad%e5%bf%83%e4%bd%93%e3%81%ae%e8%a4%87%e8%a3%bd","status":"publish","type":"post","link":"http:\/\/www.seibutsushi.net\/blog\/2008\/09\/570.html","title":{"rendered":"\u7d30\u80de\u5468\u671f\u3068\u4e2d\u5fc3\u4f53\u306e\u8907\u88fd"},"content":{"rendered":"<p><img loading=\"lazy\" alt=\"%E7%B4%B0%E8%83%9E%E3%82%B5%E3%82%A4%E3%82%AF%E3%83%AB.jpg\" src=\"\/blog\/wp-content\/uploads\/%E7%B4%B0%E8%83%9E%E3%82%B5%E3%82%A4%E3%82%AF%E3%83%AB.jpg\" width=\"512\" height=\"384\" \/><br \/>\n\u3000<br \/>\n<span style=\"color:#6666ff;\">\u30fb\u7d30\u80de\u5206\u88c2\uff08\u21d2\u300c\u7a2e\u300d\u306e\u4fdd\u5b58\uff09\u306f\u751f\u7269\u304c\u751f\u7269\u305f\u308b\u975e\u5e38\u306b\u91cd\u8981\u306a\u6a5f\u80fd<br \/>\n\u30fb\u7d30\u80de\u5206\u88c2\u306e\u969b\u306b\u4e2d\u5fc3\u3068\u306a\u3063\u3066\u50cd\u304f\u306e\u304c\u4e2d\u5fc3\u4f53\u3002\u4e2d\u5fc3\u4f53\u304c\u306a\u3044\u3068\u3001\u3046\u307e\u304f\u7d30\u80de\u5206\u88c2\u3067\u304d\u306a\u3044\u3002<br \/>\n\u30fb\u66f4\u306b\u3001\u4e2d\u5fc3\u4f53\u306e\u8907\u88fd\u306f\u67d3\u8272\u4f53\u306e\u8907\u88fd\u306b\u5148\u884c\u3057\u3001\u9a5a\u304f\u3079\u304d\u3053\u3068\u306b\u4e2d\u5fc3\u4f53\u3092\u69cb\u6210\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u308b\u9818\u57df\u306f\uff24\uff2e\uff21\u306b\u306f\u5b58\u5728\u3057\u306a\u3044\u3002<br \/>\n\u30fb\u3053\u308c\u3089\u306e\u3053\u3068\u304b\u3089\u8a00\u3048\u308b\u3053\u3068\u306f\u3001\u4e2d\u5fc3\u4f53\u306b\u3064\u3044\u3066\u8abf\u3079\u3066\u3044\u304f\u3053\u3068\u306f\u3001\u73fe\u5728\u3082\u307e\u3060\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u306a\u3044\u751f\u7269\u306e\u8d77\u6e90\uff08\uff32\uff2e\uff21\u30ef\u30fc\u30eb\u30c9\u3001\uff24\uff2e\uff21\u30ef\u30fc\u30eb\u30c9\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u30ef\u30fc\u30eb\u30c9etc.\uff09\u306b\u3082\u5927\u304d\u304f\u95a2\u4fc2\u3057\u3066\u304f\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3001\u3068\u3044\u3046\u3053\u3068\u3002<\/span><br \/>\n\u3000\u3000<br \/>\n\u3068\u3044\u3046\u3053\u3068\u3067\u3053\u306e\u9593\u5f53\u30d6\u30ed\u30b0\u3067\u3082\u4e2d\u5fc3\u4f53\u306b\u95a2\u3059\u308b\u6295\u7a3f\u304c\u7d9a\u3044\u3066\u3044\u307e\u3059\u3002<br \/>\n\u3000\u3000<br \/>\n\u4e00\u65b9\u7d30\u80de\u5206\u88c2\u306b\u95a2\u3057\u3066\u306f\u3001\u300c\u7d30\u80de\u5468\u671f\u300d\u3068\u3044\u3046\u6982\u5ff5\u3092\u4f7f\u3063\u3066\u30011\u500b\u306e\u7d30\u80de\u304c\u305f\u3069\u308b\u4e00\u9023\u306e\u9806\u5e8f\u3060\u3063\u305f\u51fa\u6765\u4e8b\uff08G1\u2192S\u2192G2\u2192M\uff09\u306e\u8ffd\u6c42\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002<br \/>\n\u306a\u304a\u3053\u306e\u30b5\u30a4\u30af\u30eb\u306e\u5185\u3001<span style=\"color:#ff3300;\">\u4e2d\u5fc3\u4f53\u306e\u8907\u88fd\uff08\u6b63\u78ba\u306b\u306f\u4e2d\u5fc3\u5c0f\u4f53\u306e\u89e3\u96e2\uff09\u306fG1\u671f\u306b\u8d77\u3053\u308a\u3001\u67d3\u8272\u4f53\uff08DNA\uff09\u306e\u8907\u88fd\u306f\u6b21\u306e\u6bb5\u968eS\u671f\u306b\u8d77\u3053\u308a\u307e\u3059\u3002<\/span><br \/>\n\u7d30\u80de\u5206\u88c2\u3068\u3044\u3046\u751f\u7269\u306b\u3068\u3063\u3066\u306e\u4e00\u5927\u30a4\u30d9\u30f3\u30c8\u3092\u958b\u59cb\u3055\u305b\u308b\u91cd\u8981\u306a\u6a5f\u80fd\u3092\u4e2d\u5fc3\u4f53\u304c\u62c5\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3059\u3002<br \/>\n\u3000\u3000<br \/>\n\u3068\u3053\u308d\u3067\u3053\u306e\u4e2d\u5fc3\u4f53\u306e\u8907\u88fd\u306f\u3069\u306e\u3088\u3046\u306a\u3000<span style=\"color:#ff3300;\">\u300c\u5408\u56f3\u300d<\/span>\u3000\u3092\u3082\u3068\u306b\u958b\u59cb\u3055\u308c\u308b\u306e\u304b\uff1f<br \/>\n\u305d\u306e\u69cb\u9020\u3092\u8ffd\u53ca\u3059\u308b\u306e\u304c\u4eca\u56de\u306e\u30c6\u30fc\u30de\u3067\u3059\u3002<\/p>\n<p><!--more--><br \/>\n\u3044\u3064\u3082\u306e\u5fdc\u63f4\u304a\u9858\u3044\u3057\u307e\u3059\u3002<br \/>\n<a href=\"http:\/\/blog.with2.net\/link.php?548466\" target=\"_blank\"><img alt=\"\u30d6\u30ed\u30b0\u30e9\u30f3\u30ad\u30f3\u30b0\u30fb\u4eba\u6c17\u30d6\u30ed\u30b0\u30e9\u30f3\u30ad\u30f3\u30b0\u3078\" src=\"\/blog\/wp-content\/uploads\/banner_04.gif\" \/><\/a><br \/>\n<a href=\"http:\/\/science.blogmura.com\/\" target=\"_blank\"><img loading=\"lazy\" height=\"15\" alt=\"\u306b\u307b\u3093\u30d6\u30ed\u30b0\u6751 \u79d1\u5b66\u30d6\u30ed\u30b0\u3078\" src=\"http:\/\/science.blogmura.com\/img\/science80_15.gif\" width=\"80\" \/><\/a><br \/>\n<a href=\"http:\/\/blogranking.fc2.com\/in.php?id=92199\" target=\"_blank\"><img src=\"\/blog\/wp-content\/uploads\/pic\/e_03.gif\" \/><\/a><br \/>\n\u3000<br \/>\n\u3000<br \/>\n<span style=\"color:#ff3300;\">\u25a0\u30b5\u30a4\u30af\u30ea\u30f3\u4f9d\u5b58\u6027\u30ad\u30ca\u30fc\u30bc\uff12-\u30b5\u30a4\u30af\u30ea\u30f3E (Cdk2-E)\u8907\u5408\u4f53<\/span><br \/>\n\u4e2d\u5fc3\u4f53\u306e\u8907\u88fd\u306f\u30b5\u30a4\u30af\u30ea\u30f3\u4f9d\u5b58\u6027\u30ad\u30ca\u30fc\u30bc\uff12-\u30b5\u30a4\u30af\u30ea\u30f3E (Cdk2-E)\u8907\u5408\u4f53\u306e\u6d3b\u6027\u3092\u901a\u3058\u3066\u5236\u5fa1\u3055\u308c\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n<img loading=\"lazy\" alt=\"%E7%B4%B0%E8%83%9E%E5%91%A8%E6%9C%9F.bmp\" src=\"\/blog\/wp-content\/uploads\/%E7%B4%B0%E8%83%9E%E5%91%A8%E6%9C%9F.bmp\" width=\"596\" height=\"266\" \/><br \/>\n\u753b\u50cf\u306f<a href=\"http:\/\/www.sc.fukuoka-u.ac.jp\/~bc1\/Biochem\/checkpnt.htm\">\u751f\u5316\u5b66<\/a>\u306e\u57fa\u790e\u304b\u3089\u304a\u501f\u308a\u3057\u307e\u3057\u305f<br \/>\n\u3000\u3000<\/p>\n<blockquote><p>\u5897\u6b96\u523a\u6fc0\u306b\u3088\u308a\u30b5\u30a4\u30af\u30ea\u30f3D\u304c\u5408\u6210\u3055\u308c\uff0cCDK4\u3068\u7d50\u5408\u3059\u308b\u3002\u8907\u5408\u4f53\u306fCAK\u306b\u3088\u308a\u30ea\u30f3\u9178\u5316\u3055\u308c\u6d3b\u6027\u5316\u3055\u308c\uff0c\u6b21\u3044\u3067Rb\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30ea\u30f3\u9178\u5316\u3059\u308b\u3002Rb\u304c\u30ea\u30f3\u9178\u5316\u3055\u308c\u308b\u3068\u7d50\u5408\u3057\u3066\u3044\u308b\u8ee2\u5199\u56e0\u5b50E2F\u304c\u96e2\u308c\uff0c\u30b5\u30a4\u30af\u30ea\u30f3E\u306a\u3069\u306eS\u671f\u9032\u884c\u3084DNA\u8907\u88fd\u306b\u5fc5\u8981\u306a\u907a\u4f1d\u5b50\u7fa4\u306e\u767a\u73fe\u304c\u8a98\u5c0e\u3055\u308c\u308b\u3002<br \/>\n\u30b5\u30a4\u30af\u30ea\u30f3E\u306fCDK2\u306b\u7d50\u5408\u3057\u3066Rb\u3092\u3055\u3089\u306b\u6d3b\u6027\u5316\u3057\u3066\u81ea\u3089\u306e\u767a\u73fe\u3092\u4ea2\u9032\u3059\u308b\u3068\u3068\u3082\u306b\uff0cp27Kip1\uff08CKI\u306e1\u3064\uff09\u3092\u30ea\u30f3\u9178\u5316\u3057\u3066\u305d\u306e\u5206\u89e3\u3092\u4fc3\u9032\u3059\u308b\u3002\u3053\u308c\u3089\u306b\u3088\u308a\uff0cS\u671f\u3078\u306e\u9032\u884c\u304c\u5b9f\u73fe\u3059\u308b\u3002\u5e7e\u3064\u304b\u306e\u6bb5\u968e\u3067\uff0cCKI\u306fS\u671f\u3078\u306e\u79fb\u884c\u3092\u6291\u5236\u3059\u308b\u3002S\u671f\u306b\u5165\u308b\u3068\u30b5\u30a4\u30af\u30ea\u30f3E\u306f\u30e6\u30d3\u30ad\u30c1\u30f3-\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u7cfb*\u3067\u5206\u89e3\u3055\u308c\u308b\u3002<\/p><\/blockquote>\n<p>\u56f3\u4e2dpre-RC\u306e\u6d3b\u6027\u5316\u3068\u306f\u3001DNA-\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\uff1d\u8907\u88fd\u524d\u8907\u5408\u4f53\uff08pre-replicative complex: pre-RC\uff09\u304c\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u3001DNA\u8907\u88fd\u3092\u958b\u59cb\u3059\u308b\u8d77\u70b9\u3068\u306a\u308b\u7269\u8cea\u3067\u3059\u3002<br \/>\n\u3053\u308c\u3068\u307b\u307c\u540c\u6642\u671f\u306b\u4e2d\u5fc3\u4f53\u306e\u8907\u88fd\u306f\u958b\u59cb\u3055\u308c\u307e\u3059\u3002<span style=\"color:#ff3300;\">\u4e2d\u5fc3\u4f53\u4e0a\u306b\u3042\u308bNPM\uff08\u30cc\u30af\u30ec\u30aa\u30d5\u30a9\u30b9\u30df\u30f3\u3068\u3044\u3046\u9175\u7d20\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u6838\u5c0f\u4f53\u306e\u69cb\u6210\u8981\u7d20\u3067\u3082\u3042\u308b\u3002\uff09\u304cCdk2-E\u8907\u5408\u4f53\u306b\u3088\u308b\u30ea\u30f3\u9178\u5316\u3092\u53d7\u3051\u3066\u4e2d\u5fc3\u4f53\u304b\u3089\u96e2\u308c\u308b\u3053\u3068\u306b\u3088\u308a\u8907\u88fd\u304c\u958b\u59cb\u3055\u308c\u308b\u3068\u3044\u3046<\/span>\u5b9f\u9a13\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u306a\u304aNPM\u3068\u3044\u3046\u7269\u8cea\u306f\u3001\u6709\u7cf8\u5206\u88c2\u6642\u306b\u518d\u3073\u4e2d\u5fc3\u4f53\u4e0a\u306b\u623b\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u5206\u88c2\u5f8c\u306e\u5a18\u7d30\u80de\u306e\u4e2d\u5fc3\u4f53\u304cNPM\u3092\u3082\u3064\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u3053\u3068\u304b\u3089NPM\u304c\u4e2d\u5fc3\u4f53\u8907\u88fd\u306b\u304a\u3051\u308b\u3042\u308b\u7a2e\u306e\u30e9\u30a4\u30bb\u30f3\u30b9\u56e0\u5b50\u3067\u306f\u306a\u3044\u304b\uff1f\u3068\u6ce8\u76ee\u3055\u308c\u59cb\u3081\u3066\u3044\u307e\u3059\u3002<br \/>\n\u3000<br \/>\n<span style=\"color:#ff3300;\">\u25a0\u5897\u6b96\u523a\u6fc0<\/span><br \/>\n\u3068\u3053\u308d\u3067\u4e0a\u8a18\u56f3\u306e\u4e00\u756a\u8d77\u70b9\u306b\u306a\u3063\u3066\u3044\u308b\u306e\u304c\u300c\u5897\u6b96\u523a\u6fc0\u300d\u3067\u3059\u3002<br \/>\n\u591a\u7d30\u80de\u751f\u7269\u306e\u5834\u5408\u7d30\u80de\u5468\u671f\u30a8\u30f3\u30b8\u30f3\uff08\u30b5\u30a4\u30af\u30ea\u30f3\u30fbCDK\uff09\u304c\u5b8c\u5168\u306b\u6a5f\u80fd\u3057\u3066\u3044\u3066\u3082\u3053\u306e\u300c\u5897\u6b96\u523a\u6fc0\uff1d\u5897\u6b96\u56e0\u5b50\u300d\u304c\u4e0e\u3048\u3089\u308c\u306a\u3044\u3068\u5168\u3066\u306e\u8907\u88fd\u30fb\u5897\u6b96\u306f\u59cb\u307e\u3089\u306a\u3044\u3002<br \/>\n\u5897\u6b96\u56e0\u5b50\u3068\u3057\u3066\u306f\u3001\uff11\uff0e\u7d30\u80de\u3084\u6297\u539f\u3068\u306e\u63a5\u89e6\u3000\uff12\uff0e\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30af\u30b9\u3068\u306e\u63a5\u89e6\u3000\uff13\uff0e\u5206\u6ccc\u6027\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u56e0\u5b50\u3068\u306e\u53cd\u5fdc\u3000\uff14\uff0e\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u3068\u306e\u53cd\u5fdc\u306a\u3069\u304c\u3042\u308b\u3002\u3053\u306e\u3088\u3046\u306b\u3072\u3068\u3064\u306e\u7d30\u80de\u304c\u5206\u88c2\u3059\u308b\u306b\u306f\u4ed6\u306e\u7d30\u80de\u304b\u3089\u306e\u30b7\u30b0\u30ca\u30eb\u304c\u3042\u308b\u3053\u3068\u306e\u898b\u9003\u305b\u307e\u305b\u3093\u3002<br \/>\n\u3000<br \/>\n\u307e\u305f\u3053\u308c\u3089<span style=\"color:#ff3300;\">\u5897\u6b96\u56e0\u5b50\u2192\u7d30\u80de\u5468\u671f\u30a8\u30f3\u30b8\u30f3\uff08\u30b5\u30a4\u30af\u30ea\u30f3\u30fbCDK\uff09\u2192\u8907\u88fd\u30fb\u5897\u6b96\u904e\u7a0b<\/span>\u3067\u50cd\u304f\u8981\u7d20\u306f\u3001\u4f53\u7d30\u80de\u3001\u5e79\u7d30\u80de\u3001\u521d\u671f\u80da\u767a\u751f\u904e\u7a0b\u3067\u305d\u308c\u305e\u308c\u7570\u306a\u308a\u307e\u3059\u3002<br \/>\n\u7d30\u80de\u5897\u6b96\u306e\u539f\u70b9\u3067\u3042\u308b\u521d\u671f\u80da\u767a\u751f\u904e\u7a0b\u3067\u306f\u3001\u30e2\u30eb\u30d5\u30a9\u30b2\u30f3\u3068\u3044\u3046\u30b7\u30b0\u30ca\u30eb\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u5897\u6b96\u56e0\u5b50\u3068\u306a\u308a\u307e\u3059\u3002<br \/>\n\u3000\u3000<br \/>\n<span style=\"color:#ff3300;\">\u25a0\u307e\u3068\u3081<\/span><br \/>\n\u7d30\u80de\u5468\u671f\u3068\u4e2d\u5fc3\u4f53\u306e\u8907\u88fd\u3068\u3044\u3046\u89b3\u70b9\u3067\u4eca\u56de\u8abf\u67fb\u3092\u884c\u3044\u307e\u3057\u305f\u304c\u3001\u771f\u6838\u751f\u7269\u306b\u304a\u3044\u3066\u306f\u5897\u6b96\u56e0\u5b50\u304c\u8907\u88fd\u306e\u5408\u56f3\u3092\u51fa\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<br 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