{"id":558,"date":"2008-09-07T12:20:56","date_gmt":"2008-09-07T03:20:56","guid":{"rendered":"http:\/\/testwww.seibutsushi.net\/blog\/2008\/09\/529.html"},"modified":"2008-09-07T12:20:56","modified_gmt":"2008-09-07T03:20:56","slug":"%e5%88%86%e8%a3%82%e5%bd%a2%e6%88%90%e3%82%92%e6%8b%85%e3%81%86%ef%bd%9a%e3%83%aa%e3%83%b3%e3%82%b0%ef%bc%88%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%e9%9b%86%e5%90%88%e4%bd%93%ef%bc%89","status":"publish","type":"post","link":"http:\/\/www.seibutsushi.net\/blog\/2008\/09\/558.html","title":{"rendered":"\u5206\u88c2\u5f62\u6210\u3092\u62c5\u3046\uff3a\u30ea\u30f3\u30b0\uff08\u30bf\u30f3\u30d1\u30af\u8cea\u96c6\u5408\u4f53\uff09"},"content":{"rendered":"<p>\uff10\uff19\u6708\uff10\uff15\u65e5\u306e\u8a18\u4e8b\u3001\u300c\u539f\u6838\u7d30\u80de\u306e\u5206\u88c2\u300d\u3067\u7d39\u4ecb\u3055\u308c\u305f\u5206\u88c2\u884c\u70ba\u306e\u5f79\u5272\u3092\u62c5\u3046\u3001\u3010FtsZ\u30bf\u30f3\u30d1\u30af\u8cea\u3011\u3067\u69cb\u6210\u3055\u308c\u305f\uff3a\u30ea\u30f3\u30b0\u306b\u3064\u3044\u3066\u66f8\u304d\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<br \/>\n\uff1e\uff24\uff2e\uff21\u8907\u88fd\u304c\u7d42\u4e86\u3057\u3001\u65b0\uff24\uff2e\uff21\u306e\u4e00\u65b9\u304c\u3001\u819c\u7d50\u5408\u578bDNA\u8ee2\u4f4d\u9175\u7d20(\uff1dFtsK)\u88ab\u819c\u3092\u901a\u904e\u3059\u308b\u3068\u3001\u771f\u6838\u751f\u7269\u306e\u30c1\u30e5\u30fc\u30d6\u30ea\u30f3(\uff1d\u7ba1\u72b6\u7e4a\u7dad\u675f)\u3068\u4f3c\u305f\u30bf\u30f3\u30d1\u30af\u8cea(\uff1dFtsZ)\u304c\u3001\u7d30\u80de\u4e2d\u592e\u90e8\u3067\u50cd\u304d\u59cb\u3081\u307e\u3059\u3002FtsZ\u306f\u53ce\u7e2e\u74b0\u3092\u5f62\u6210\u3057\u3001\u30ea\u30f3\u30b0\u72b6\u306b\u7d5e\u308a\u8fbc\u3080\u3088\u3046\u306a\u52d5\u304d\u3067\u3001\u7d30\u80de\u4e2d\u592e\u90e8\u306b\u304f\u3073\u308c\u3092\u751f\u3058\u3055\u305b\u3001\u7d30\u80de\u9593\u9694\u58c1\u3092\u3064\u304f\u308a\u5206\u88c2\u3057\u307e\u3059\u3002<br \/>\n\u5fdc\u63f4\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3057\u307e\u3059\u3002<br \/>\n<a href=\"http:\/\/blog.with2.net\/link.php?548466\" target=\"_blank\"><img alt=\"\u30d6\u30ed\u30b0\u30e9\u30f3\u30ad\u30f3\u30b0\u30fb\u4eba\u6c17\u30d6\u30ed\u30b0\u30e9\u30f3\u30ad\u30f3\u30b0\u3078\" src=\"\/blog\/wp-content\/uploads\/banner_04.gif\" \/><\/a> <a href=\"http:\/\/science.blogmura.com\/\" target=\"_blank\"><img loading=\"lazy\" height=\"15\" alt=\"\u306b\u307b\u3093\u30d6\u30ed\u30b0\u6751 \u79d1\u5b66\u30d6\u30ed\u30b0\u3078\" src=\"http:\/\/science.blogmura.com\/img\/science80_15.gif\" width=\"80\" \/><\/a> <a href=\"http:\/\/blogranking.fc2.com\/in.php?id=92199\" target=\"_blank\"><img src=\"\/blog\/wp-content\/uploads\/pic\/e_03.gif\" \/><\/a><br \/>\n\u3000<\/p>\n<p><!--more--><br \/>\n<img loading=\"lazy\" alt=\"nrm1745-f3.jpg\" src=\"\/blog\/wp-content\/uploads\/nrm1745-f3.jpg\" width=\"500\" height=\"287\" \/><br \/>\n\u25cf\u65e2\u5b58\u306e\u7814\u7a76\u3067\u4ee5\u4e0b\u306e\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3057\u305f\u3002<br \/>\n\u30fb\uff3a\u30ea\u30f3\u30b0\u306f\u3001FtsZ \u30bf\u30f3\u30d1\u30af\u8cea\u306812\u500b\u306e\u4ed6\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u91cd\u5408\u3057\u3066\u3001Z\u30ea\u30f3\u30b0\u3092\u7d44\u307f\u7acb\u3066\u3066\u3044\u308b\u3002<br \/>\n\u305d\u308c\u305e\u308c\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5f79\u5272\u306f\u89e3\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u3002<br \/>\n\u30fbFtsZ \u30bf\u30f3\u30d1\u30af\u8cea\u306fFtsA\u305f\u3093\u3071\u304f\u8cea\u3092\u30a2\u30f3\u30ab\u30fc\u3068\u3057\u3066\u3001\u819c\u306b\u7e4b\u304e\u6b62\u3081\u3089\u308c\u3066\u3044\u308b\u3002<br \/>\n\u30fbFtsZ \u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u30c1\u30e5\u30fc\u30d6\u30ea\u30f3\u3068\u547c\u3070\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5358\u4f4d\u3068\u3057\u3066\u69cb\u6210\u3057\u3066\u3044\u308b\u4e2d\u5fc3\u4f53\u3084\u4e2d\u5fc3\u4f53\u304b\u3089\u4f38\u3073\u308b\u5fae\u5c0f\u7ba1\u3068\u4f3c\u305f\u5206\u5b50\u69cb\u9020\u3092\u6301\u3063\u3066\u3044\u308b\u3002\u7e4a\u7dad\u72b6\u69cb\u9020\u3092\u3068\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002<br \/>\n\u30fbFtsZ \u30bf\u30f3\u30d1\u30af\u8cea\u306f GTP \u3068\u7d50\u5408\u3057\u3066\u3044\u308b\u6642\u306b\u306f\u76f4\u7dda\u72b6\u306e\u539f\u7e4a\u7dad\u3092\u69cb\u6210\u3059\u308b\u3002<br \/>\nGDP\uff08GTP \u306e\u5206\u89e3\u7523\u7269\uff09\u3068\u7d50\u5408\u3057\u3066\u3044\u308b\u3068\u304d\u306b\u306f\u8457\u3057\u304f\u66f2\u304c\u3063\u305f\u539f\u7e4a\u7dad\u306e\u69cb\u9020\u3092\u69cb\u6210\u3059\u308b\u3002<br \/>\n\u25cf\u6700\u8fd1\u306eReconstitution of Contractile FtsZ Rings in Liposomes<br \/>\np. 792-794. \u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u3001<br \/>\nFtsZ \u30bf\u30f3\u30d1\u30af\u8cea\u5358\u72ec\u3067\u3082\u30ea\u30f3\u30b0\u3092\u5f62\u6210\u3057\u3066\u819c\u80de\u3092\u304f\u3073\u308c\u8fbc\u307e\u305b\u308b\u80fd\u529b\u3092\u6301\u3064\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304d\u305f\u3002<\/p>\n<blockquote><p>\u8457\u8005\u3089\u306f\u307e\u305a FtsZ \u30bf\u30f3\u30d1\u30af\u8cea\u306e C \u672b\u7aef\u3092\u758e\u6c34\u6027\u3078\u30ea\u30c3\u30af\u30b9\u3067\u7f6e\u304d\u63db\u3048\uff0cFtsA \u306e\u4ef2\u4ecb\u306a\u3057\u306b\u819c\u306b\u7d50\u5408\u3067\u304d\u308b\u3088\u3046\u306b\u3057\u307e\u3057\u305f \uff08FtsZ-mts\uff09\u3002\u306a\u304a\uff0cFtsZ-mts \u306b\u306f YFP \u3068\u3044\u3046\u86cd\u5149\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u7d50\u5408\u3055\u308c\u3066\u304a\u308a\uff0c\u86cd\u5149\u89b3\u5bdf\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002 \u3053\u308c\u3092\u30ea\u30dd\u30bd\u30fc\u30e0\uff08\u4eba\u5de5\u7684\u306b\u5408\u6210\u3055\u308c\u305f\u30ea\u30f3\u8102\u8cea\u4e8c\u5206\u5b50\u5c64\u819c\u306e\u5c0f\u80de\uff09\uff0cGTP\uff08FtsZ \u306e\u91cd\u5408\u306b\u5fc5\u8981\u306a\u5206\u5b50\uff09 \u3068\u5171\u306b\u7f6e\u3044\u305f\u3068\u3053\u308d\uff0cFtsZ-mts \u304c\u30ea\u30dd\u30bd\u30fc\u30e0\u5185\u90e8\u306b\u53d6\u308a\u8fbc\u307e\u308c\u3066\u8907\u6570\u306e Z \u30ea\u30f3\u30b0\u3092\u5f62\u6210\u3057\u307e\u3057\u305f\u3002 \u521d\u3081 FtsZ-mts \u306f\u8584\u3044\u86cd\u5149\u306e\u30ea\u30f3\u30b0\u3092\u5f62\u6210\u3057\uff0c\u30ea\u30f3\u30b0\u304c\u30ea\u30dd\u30bd\u30fc\u30e0\u72b6\u3092\u524d\u5f8c\u306b\u79fb\u52d5\u3057\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u30ea\u30f3\u30b0\u540c\u58eb\u304c\u5408\u308f\u3055\u308b\u3068\uff0c \u660e\u308b\u3044\u86cd\u5149\u306e\u30ea\u30f3\u30b0\u3068\u306a\u308a\uff0c\u305d\u306e\u5834\u3067\u30ea\u30dd\u30bd\u30fc\u30e0\u306e\u304f\u3073\u308c\u8fbc\u307f\u304c\u8d77\u3053\u3063\u305f\u305d\u3046\u3067\u3059\u3002 \u9006\u306b GTP \u6fc3\u5ea6\u3092\u5f90\u3005\u306b\u6e1b\u3089\u3057\u305f\u3068\u3053\u308d\uff0cZ \u30ea\u30f3\u30b0\u306e\u86cd\u5149\u304c\u8584\u304f\u306a\u308a\uff0c\u540c\u6642\u306b\u30ea\u30dd\u30bd\u30fc\u30e0\u306e\u304f\u3073\u308c\u304c\u89e3\u6d88\u3055\u308c\u305f\u305d\u3046\u3067\u3059\u3002<br \/>\n\u30ad\u30cd\u30b7\u30f3\u306e\u3088\u3046\u306a\u30e2\u30fc\u30bf\u30fc\u5206\u5b50\u306f\u5b58\u5728\u3057\u306a\u3044\u306e\u3067\uff0c \u4f55\u304b\u5225\u306e\u529b\u3067\u819c\u3092\u5909\u5f62\u3057\u3066\u3044\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002FtsZ \u306f GTP \u3068\u7d50\u5408\u3057\u3066\u3044\u308b\u6642\u306b\u306f\u76f4\u7dda\u72b6\u306e\u539f\u7e4a\u7dad\u3092\u69cb\u6210\u3057\u307e\u3059\u304c\uff0c GDP\uff08GTP \u306e\u5206\u89e3\u7523\u7269\uff09\u3068\u7d50\u5408\u3057\u3066\u3044\u308b\u3068\u304d\u306b\u306f\u8457\u3057\u304f\u66f2\u304c\u3063\u305f\u539f\u7e4a\u7dad\u306e\u69cb\u9020\u3092\u3068\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002 \u3059\u306a\u308f\u3061 FtsZ \u306f\uff0cGTP \u304c\u5206\u89e3\u3055\u308c\u3066\u51fa\u308b\u30a8\u30cd\u30eb\u30ae\u30fc\u306b\u3088\u3063\u3066\u5909\u5f62\u3057\uff0c\u539f\u7e4a\u7dad\u3082\u66f2\u304c\u308a\uff0c \u7d50\u679c\u3068\u3057\u3066\u30ea\u30dd\u30bd\u30fc\u30e0\u304c\u304f\u3073\u308c\u8fbc\u3093\u3067\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<br \/>\n\u30ea\u30f3\u30b0\u306e\u5f62\u6210\u306b\u3082\u8b0e\u304c\u3042\u308a\u307e\u3059\u3002\u539f\u7e4a\u7dad\u304c\u3089\u305b\u3093\u72b6\u306b\u4f38\u3073\u305a\uff0c\u9589\u3058\u305f\u30ea\u30f3\u30b0\u3092\u69cb\u6210\u3067\u304d\u308b\u4ed5\u7d44\u307f\u306f\u4e0d\u601d\u8b70\u3067\u3059\u3002 \u8457\u8005\u3089\u306f FtsZ \u306e\u539f\u7e4a\u7dad\u304c\u53ce\u7e2e\u306e\u529b\u3092\u6301\u3064\u305f\u3081\u306b\uff0c\u6700\u5c0f\u306e\u76f4\u5f84\u3092\u306a\u3059\u90e8\u5206\u306b\u914d\u7f6e\u3059\u308b\uff0c \u3059\u306a\u308f\u3061\u819c\u80de\u306e\u8ef8\u306b\u5782\u76f4\u306a\u4f4d\u7f6e\u306b\u30ea\u30f3\u30b0\u3092\u5f62\u6210\u3059\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u539f\u7e4a\u7dad\u306e\u96c6\u5408\u81ea\u4f53\uff0c \u89b3\u5bdf\u304b\u3089\u306f\u539f\u7e4a\u7dad\u540c\u58eb\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u308b\u3082\u306e\u3067\u306f\u306a\u3044\u3068\u898b\u3089\u308c\u3066\u304a\u308a\uff0c\u304a\u305d\u3089\u304f\u539f\u7e4a\u7dad\u306e\u7d50\u5408\u306b\u3088\u3063\u3066\u819c\u304c\u6b6a\u3093\u3060\u7d50\u679c\uff0c \u6b6a\u3093\u3060\u9818\u57df\u306b\u539f\u7e4a\u7dad\u304c\u7d50\u5408\u3057\u3084\u3059\u304f\u306a\u308a\uff0c\u4e92\u3044\u306b\u540c\u3058\u65b9\u5411\u3092\u5411\u304f\u3088\u3046\u306b\u96c6\u307e\u3063\u3066\u3044\u308b\u3068\u63a8\u6e2c\u3055\u308c\u307e\u3057\u305f\u3002<br \/>\n\u4eca\u56de\u306e\u7d50\u679c\u304b\u3089\uff0cFtsZ \u306f\u6bd4\u8f03\u7684\u5358\u7d14\u306a\u6a5f\u69cb\u306b\u3088\u3063\u3066\u53ce\u7e2e\u30ea\u30f3\u30b0\u3092\u69cb\u6210\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002 \u3053\u306e\u4ed5\u7d44\u307f\u306f\u539f\u59cb\u7684\u306a\u7d30\u80de\u5206\u88c2\u306e\u4ed5\u7d44\u307f\u3068\u3057\u3066\u3082\u7d0d\u5f97\u3067\u304d\u308b\u3082\u306e\u3067\uff0c \u304a\u305d\u3089\u304f\u4f3c\u305f\u3088\u3046\u306a\u5206\u5b50\u304c\u7d30\u80de\u5206\u88c2\u306e\u8d77\u6e90\u306b\u95a2\u308f\u3063\u3066\u3044\u305f\u306e\u3067\u3057\u3087\u3046\u3002 \u306a\u304a FtsZ \u306e\u5834\u5408\uff0c\u5358\u72ec\u3067\u30ea\u30dd\u30bd\u30fc\u30e0\u3092\u304f\u3073\u308c\u8fbc\u307e\u305b\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u3059\u304c\uff0c\u304f\u3073\u308c\u5207\u308b\u3053\u3068\u306f\u3067\u304d\u3066\u3044\u307e\u305b\u3093\u3002 \u5206\u88c2\u306e\u6700\u5f8c\u306e\u6bb5\u968e\u306b\u306f\u307e\u305f\u5225\u306e\u30bf\u30f3\u30d1\u30af\u8cea\uff0c\u3042\u308b\u3044\u306f\u5225\u306e\u529b\u5b66\u7684\u6a5f\u69cb\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3082\u306e\u3068\u601d\u308f\u308c\u307e\u3059\u3002<br \/>\n\uff08<span style=\"color:black\"><b><span style=\"font-size:12px\"><a href=\"http:\/\/www2.tba.t-com.ne.jp\/nakada\/takashi\/scripts\/molcell.html\">\u96d1\u8a18\uff08\u30cb\u30e5\u30fc\u30b9\u306a\u3069\uff09 \uff0d \u5206\u5b50\u7d30\u80de\u5b66\u3088\u308a<\/a><\/span><\/b><\/span>\u3011\uff09<\/p><\/blockquote>\n<p>\uff3a\u30ea\u30f3\u30b0\u5f62\u6210\u306b\u304a\u3051\u308b\u3001FtsZ\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5206\u89e3\u4f5c\u7528\u306e\u969b\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u767a\u751f\u306b\u3088\u3063\u3066\u3001\u539f\u7e4a\u7dad\u306e\u5f62\u3092\u30ea\u30f3\u30b0\u72b6\u306b\u5909\u5f62\u3057\u3001\u53ce\u7e2e\u4f5c\u7528\u304c\u8d77\u304d\u3066\u3044\u308b\u3002<br \/>\n\u771f\u6838\u7d30\u80de\u306e\u30e2\u30fc\u30bf\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ad\u30cd\u30b7\u30f3\u306e\u5834\u5408\u306f\u3001\uff21\uff34\uff30\u5206\u89e3\u9175\u7d20\u3067\u3042\u308b\u982d\u90e8\u306e\u52a0\u6c34\u5206\u89e3\u306e\u4f5c\u7528\u306b\u3088\u308a\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u767a\u751f\u3055\u305b\u81ea\u8eab\u306e\u7acb\u4f53\u69cb\u9020\u3092\u5909\u5316\u3055\u305b\u3001\u79fb\u52d5\u3057\u3066\u3044\u308b\u3002<br 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